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Abstract #0426

The influence of temperature on two ex vivo myelin specific imaging protocols: Inhomogeneous Magnetization Transfer and Myelin Water Imaging

Valentin H. Prevost1, Sarah Morris2,3, Andrew Yung1, Irene Vavasour1,4, Carl Michal3, Erin MacMillan1,5, Wayne G.R. Moore2,6, Cornelia Laule2,3,4,6, Alex MacKay1,3,4, and Piotr Kozlowski1,2,3,4,6

1UBC MRI Research Centre, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 3Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 4Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 5MR Clinical Science, Philips Healthcare Canada, Markam, ON, Canada, 6Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

The impact of temperature on inhomogeneous magnetization transfer (ihMT) measurements in formalin-fixed human brain was studied. White matter (WM) ihMT signal increased with temperature when a T1D-filter was applied, supporting the hypothesis that components with long T1D (>1ms) are more sensitive to temperature variations. Grey matter ihMT did not vary with temperature. This suggests a difference in T1D values between WM and GM, and confirms that several T1D components contribute to myelin ihMT. Myelin water fraction values decreased with increasing temperature, possibly due to faster exchange between water compartments. Temperature is an important factor to consider in order to characterize the microstructure.

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