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Abstract #0463

Quantitative Measurements of Carotid Atherosclerotic Plaque Compositions using in vivo T1 Mapping: Validation by Histology

Huiyu Qiao1, Dongye Li1, Hualu Han1, Yongjun Han1, Jingli Cao2,3, Haikun Qi4, Huijun Chen1, Tao Wang5, Huimin Xu6, and Xihai Zhao1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 2Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 3China National Clinical Research Center for Neurological Diseases, Beijing, China, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 5Department of Neurosurgery, Peking University Third Hospital, Beijing, China, 6Department of Radiology, Peking University Third Hospital, Beijing, China

Plaque compositional features are effective indicators for vulnerability and associated with ischemic stroke risk. Multicontrast vessel wall imaging has been utilized to characterize plaque compositions but this technique is time consuming and dependent on reviewer’s experience. Therefore, it is important to characterize plaque compositions with time-efficient imaging approach. This study sought to determine T1 values of carotid plaque components determined by quantitative imaging validated by histology. We found that the T1 values of intraplaque hemorrhage, necrotic core, and loose matrix were distinguishable. Our findings suggest that carotid plaque components might be distinguishable and automatically segmented on quantitative MR imaging.

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