Abstract #0487

Quantitative 23Na MRI of the human liver at 7 Tesla

Johanna Lott^1,2, Nicolas GR Behl¹, Armin M Nagel^1,3,4, Reiner Umathum¹, Peter Bachert^1,2, Mark E Ladd^1,2,5, and Tanja Platt¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Sodium (²³Na) MRI has been proposed as a potential imaging modality for the characterization of hepatic tumors and for monitoring therapy response. Up to now, only one study has been performed on implanted hepatocellular carcinomas in rats. In the present work, in-vivo ²³Na MRI of the healthy human liver is performed and to the best of our knowledge, the hepatic tissue sodium concentration is estimated for the first time. For quantitative ²³Na MRI correction methods were applied such as self-gating and B₁⁺ correction. The mean sodium concentration for three volunteers was estimated to be (27±5) mM in the liver.

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