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Abstract #0487

Quantitative 23Na MRI of the human liver at 7 Tesla

Johanna Lott1,2, Nicolas GR Behl1, Armin M Nagel1,3,4, Reiner Umathum1, Peter Bachert1,2, Mark E Ladd1,2,5, and Tanja Platt1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 5Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Sodium (23Na) MRI has been proposed as a potential imaging modality for the characterization of hepatic tumors and for monitoring therapy response. Up to now, only one study has been performed on implanted hepatocellular carcinomas in rats. In the present work, in-vivo 23Na MRI of the healthy human liver is performed and to the best of our knowledge, the hepatic tissue sodium concentration is estimated for the first time. For quantitative 23Na MRI correction methods were applied such as self-gating and B1+ correction. The mean sodium concentration for three volunteers was estimated to be (27±5) mM in the liver.

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