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Abstract #0512

Effects of ­­Carrier Frequency Mismatch on Frequency-Selective Spectral Editing

Li An1, Maria Ferraris Araneta1, Christopher Johnson1, and Jun Shen1

1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

This study investigated the effects of carrier frequency mismatch on spectral editing and its correction by frequency matching of basis functions. Full density matrix computations and Monte Carlo simulations based on MRS data collected from five healthy volunteers at 7 T were used to analyze the effects of carrier frequency mismatch on spectral editing. There were significant errors in metabolite quantification without frequency matching of basis functions when carrier frequency mismatch was generally considered negligible. By matching basis functions with the history of frequency deviation, errors in glutamate, glutamine, g-aminobutyric acid, and glutathione concentrations were significantly reduced.

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