Abstract #0515

Towards absolute quantification of brain metabolites using Electronic REference To access In vivo Concentrations (ERETIC) for MR spectroscopic imaging (MRSI)

Bijaya Thapa^1,2, Azma Mareyam¹, Jason Stockmann^1,2, Boris Keil³, Philipp Hoecht⁴, Zhe Wang⁵, Yulin V. Chang⁵, Stefan Carp^1,2, Xianqi Li^1,2, Bernhard Strasser^1,2, Lawrence Wald^1,2, and Ovidiu C. Andronesi^1,2

¹Dept. of Radiology, MGH, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Mittelhessen University of Applied Science, Giessen, Germany, ⁴Siemens Healthcare, Erlangen, Germany, ⁵Siemens Medical Solutions USA, Charlestown, MA, United States

Absolute quantification of metabolite concentration from MRSI data requires a reference signal of known concentration. An external synthetic electronic reference signal method (Electronic REference To access In vivo Concentrations – ERETIC) has shown great promise for absolute quantification and calibration. However, ERETIC based absolute quantification is challenging for MR spectroscopic imaging (MRSI) data and here we set on investigating strategies and performance of ERETIC in combination with MRSI and multi-channel receive arrays.

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