Abstract #0520

High-resolution multiparametric quantitative MRI of the cervical spinal cord at 7T: preliminary results at the early stage of multiple sclerosis

Aurélien Massire^1,2,3, Sarah Demortière^1,2,4, Pierre Lehmann^1,2,5, Henitsoa Rasoanandrianina^1,2,3, Maxime Guye^1,2, Bertrand Audoin^1,2,4, Jean Pelletier^1,2,4, and Virginie Callot^1,2,3

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³iLab-Spine - Laboratoire international - Imagerie et Biomécanique du rachis, Marseille, France, ⁴APHM, Hôpital Universitaire Timone, Service de Neurologie, Marseille, France, ⁵APHM, Hôpital Universitaire Timone, Service de Neuroradiologie, Marseille, France

In this exploratory study, a high-resolution multiparametric quantitative MRI protocol including T₁ mapping and diffusion tensor imaging was used to explore the cervical spinal cord of multiple sclerosis patients at 7T, in comparison to healthy controls. These patients were also explored at 3T to investigate the potential benefits of 7T MRI in terms of lesion detection and delineation. The obtained preliminary results showed an improved qualitative anatomical depiction when compared to clinical fields and for the first time an in vivo multiparametric quantitative characterization of the pathological cervical spinal cord in multiple sclerosis at ultra-high field.

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