Abstract #0541

Ultrashort echo time magnetization transfer (UTE-MT) imaging in the cuprizone mouse model of multiple sclerosis

Caroline Guglielmetti^1,2, Tanguy Boucneau², Peng Cao², Annemie Van der Linden³, Peder E.Z Larson^2,4, and Myriam M. Chaumeil^1,2

¹Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ²Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Pharmaceutical, Veterinary and Biomedical Sciences, Bio-Imaging Laboratory, Antwerp, Belgium, ⁴Berkeley and University of California, UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States

We first evaluated the potential of ultrashort echo time magnetization transfer (UTE-MT) and MT imaging to generate high contrast images of the healthy mouse brain.

Next, we conducted a longitudinal study to examine the temporal changes of UTE-MT ratio (UTE-MTR) and MTR following cuprizone (CPZ)-mediated demyelination, gliosis, and remyelination. UTE-MTR detected CPZ-induced alterations in white matter, subcortical, and cortical grey matter during demyelination, and persistent tissue microstructure changes in grey matter. Furthermore, UTE-MTR changes correlated significantly with myelin levels.

Altogether, we showed that UTE-MT imaging holds great potential to improve characterization of brain lesions in MS at clinical field strength.

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