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Abstract #0541

Ultrashort echo time magnetization transfer (UTE-MT) imaging in the cuprizone mouse model of multiple sclerosis

Caroline Guglielmetti1,2, Tanguy Boucneau2, Peng Cao2, Annemie Van der Linden3, Peder E.Z Larson2,4, and Myriam M. Chaumeil1,2

1Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3Pharmaceutical, Veterinary and Biomedical Sciences, Bio-Imaging Laboratory, Antwerp, Belgium, 4Berkeley and University of California, UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States

We first evaluated the potential of ultrashort echo time magnetization transfer (UTE-MT) and MT imaging to generate high contrast images of the healthy mouse brain.

Next, we conducted a longitudinal study to examine the temporal changes of UTE-MT ratio (UTE-MTR) and MTR following cuprizone (CPZ)-mediated demyelination, gliosis, and remyelination. UTE-MTR detected CPZ-induced alterations in white matter, subcortical, and cortical grey matter during demyelination, and persistent tissue microstructure changes in grey matter. Furthermore, UTE-MTR changes correlated significantly with myelin levels.

Altogether, we showed that UTE-MT imaging holds great potential to improve characterization of brain lesions in MS at clinical field strength.

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