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Abstract #0555

Improved white matter response function estimation for 3-tissue constrained spherical deconvolution

Thijs Dhollander1,2, Remika Mito1,2, David Raffelt1, and Alan Connelly1,2

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

Multi-shell multi-tissue constrained spherical deconvolution (MSMT-CSD) and single-shell 3-tissue CSD (SS3T-CSD) decompose the diffusion MRI signal in a white matter (WM) fibre orientation distribution (FOD) and grey matter (GM) and cerebrospinal fluid (CSF) compartments. An unsupervised method was recently proposed to estimate the required WM/GM/CSF response functions. In this work, we improved WM response function estimation by leveraging WM properties across b-values, resulting in better 3-tissue CSD fit to most data. Slightly beyond the scope of this work, we also make an interesting observation in developing Human Connectome Project data.

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