Abstract #0602

Quantitative magnetization transfer imaging of breast cancer: Initial results at 3T

Lori R. Arlinghaus¹, Richard D. Dortch^1,2, Hakmook Kang³, David M. Wharton⁴, Richard G. Abramson^1,2, and Thomas E. Yankeelov^5,6,7,8

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴School of Medicine, Vanderbilt University, Nashville, TN, United States, ⁵Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, United States, ⁶Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States, ⁷Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, ⁸Department of Oncology, The University of Texas at Austin, Austin, TX, United States

Quantitative MT (qMT) techniques provide measurements of the ratio of macromolecular to free water protons, or pool-size-ratio (PSR), which may be useful for detection of changes in macromolecular content of breast tumors early in the course of treatment. Here we report preliminary qMT data acquired as part of an ongoing study employing quantitative MRI to predict the response of breast tumors to neoadjuvant therapy. PSR measurements in tumors were found to be significantly reduced compared to the surrounding fibroglandular tissue in patients diagnosed with invasive breast cancer.

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