Magnetic resonance elastography (MRE) of the hippocampus has shown promise as an imaging biomarker for Alzheimer’s disease (AD). In this work, we report that MRE of the hippocampal subfields are consistent with the known cytoarchitecture. We also found softening of the hippocampal subfields in patients with AD compared to healthy controls with a more pronounced reduction in the subiculum and CA1 compared to the global hippocampus. The dentate-gyrus/CA3 was also more viscoelastic in AD (indicating greater elasticity and less viscosity), whereas no viscoelastic effect was detected globally. MRE of the subfields may provide additional information regarding hippocampal integrity in disease.
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