Abstract #0629

Fetal diffusion MRI acquisition and analysis in the developing Human Connectome Project

Daan Christiaens^1,2, Lucilio Cordero-Grande^1,2, Anthony N Price^1,2, Jana Hutter^1,2, Emer Hughes¹, Serena J Counsell¹, J-Donald Tournier^1,2, and Joseph V Hajnal^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Fetal diffusion MRI (dMRI) can offer unique insight in brain development during the period of rapid, formative growth in the third trimester of pregnancy. The developing Human Connectome Project (dHCP) aims to create a comprehensive mapping of brain connectivity development in a large neonatal and fetal imaging cohort. Here, we design a state-of-the-art acquisition and analysis pipeline for fetal dMRI, including closely integrated dynamic distortion correction and slice-to-volume motion correction. We present results in the first 125 fetal dHCP subjects acquired, demonstrating high quality motion and distortion corrected output in the large majority of subjects and across a broad age range.

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