Abstract #0638

Whole-abdomen Free-breathing Quantitative Dynamic Contrast Enhanced (DCE) MR Imaging of Pancreatic Ductal Adenocarcinoma (PDAC) with Fast T1 Mapping Using Multitasking: A Pilot Study

Nan Wang^1,2, Anthony Christodoulou¹, Srinivas Gaddam³, Lixia Wang⁴, Yibin Xie¹, Zixin Deng¹, Zhengwei Zhou¹, Wensha Yang⁵, Zhaoyang Fan¹, Richard Tuli⁵, Simon Lo³, Andrew Hendifar³, Stephen Pandol³, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Radiologic Department, Chaoyang Hospital, Beijing, China, ⁵Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

PDAC is the 3rd leading cause of cancer-related death in the US with poor prognoses. Although conventional DCE-MRI techniques have demonstrated high sensitivity and specificity in tumor delineation, the diagnosis and prognosis of PDAC continues to be challenging with currently available imaging tools. In this work, we proposed a novel Multitasking DCE technique enabling free-breathing acquisition, 3D whole-abdomen coverage, high temporal resolution (500 ms), and dynamic T1 mapping to allow for accurate quantification of tissue perfusion and vascular properties of PDAC. The in vivo feasibility of the proposed technique is demonstrated in healthy subjects and patients with PDAC.

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