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Abstract #0638

Whole-abdomen Free-breathing Quantitative Dynamic Contrast Enhanced (DCE) MR Imaging of Pancreatic Ductal Adenocarcinoma (PDAC) with Fast T1 Mapping Using Multitasking: A Pilot Study

Nan Wang1,2, Anthony Christodoulou1, Srinivas Gaddam3, Lixia Wang4, Yibin Xie1, Zixin Deng1, Zhengwei Zhou1, Wensha Yang5, Zhaoyang Fan1, Richard Tuli5, Simon Lo3, Andrew Hendifar3, Stephen Pandol3, and Debiao Li1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Radiologic Department, Chaoyang Hospital, Beijing, China, 5Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

PDAC is the 3rd leading cause of cancer-related death in the US with poor prognoses. Although conventional DCE-MRI techniques have demonstrated high sensitivity and specificity in tumor delineation, the diagnosis and prognosis of PDAC continues to be challenging with currently available imaging tools. In this work, we proposed a novel Multitasking DCE technique enabling free-breathing acquisition, 3D whole-abdomen coverage, high temporal resolution (500 ms), and dynamic T1 mapping to allow for accurate quantification of tissue perfusion and vascular properties of PDAC. The in vivo feasibility of the proposed technique is demonstrated in healthy subjects and patients with PDAC.

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