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Abstract #0643

Pancreatic perfusion modulation following glucose stimuli revealed by non-invasive Arterial Spin Labeling (ASL) MRI

Manuel Taso1, Koenraad J Mortele1, Fotini Papadopoulou1, Martin P Smith1, and David C Alsop1

1Division of MRI research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boson, MA, United States

Being able to non-invasively monitor pancreatic perfusion changes is essential for its clinical translation, but it can also prove useful in the evaluation of endocrine disorders such as diabetes. While some perfusion modification following a glucose challenge was observed with PET, ASL has not yet succeeded. We propose here an investigation of pancreatic perfusion modulation following an oral glucose challenge with background-suppressed pCASL at 3T, highlighting perfusion modulation that could be linked to pancreatic endocrine function. Such paradigm could either serve as a tool for studying endocrine disorders or provide a glucose-enhanced scan that increases SNR for diagnostic purposes.

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