Abstract #0656

Validation of diffusion models: a post-mortem MRI and histology study

Zihan Zhou¹, Qiqi Tong¹, Hongjian He¹, Keqing Zhu², Hui Lu², Lei Zhang², Qiuping Ding¹, Laura E Jonkman³, and Jianhui Zhong^1,4

¹Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, ²China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China, ³Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, Netherlands, ⁴Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

The Diffusion Kurtosis Imaging (DKI) model can successfully characterize non-Gaussian diffusion. In turn, the White Matter Tract Integrity (WMTI) model is proposed to be based on the DKI model to further characterize the intra- and extra-axonal compartments. However, the accuracy with which model parameters reflect the underlying tissue characteristics has not been tested. Here, we compared two MRI model metrics using a unique combined post-mortem MRI and histopathology approach. Preliminary results show that AWF, $$$D_{e,\perp}$$$and MD from MRI correlate strongly with myelin fraction and that $$$D_{e,\parallel}$$$ from MRI correlates strongly with astrocyte fraction.

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