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Abstract #0680

Variational vs Adversarial Autoencoders for Visualization and Interpretation of Deep Learning Features of Brain Aging

Luis Alberto Souto Maior Neto1,2, Mariana Bento3,4, David G Gobbi3,4, and Richard Frayne2,3

1Biomedical Engineering, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 2Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada, 3Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 4Calgary Image Processing and Analysis Centre, Foothills Medical Centre, Calgary, AB, Canada

Deep learning models are state-of-the-art for numerous medical imaging prediction tasks. Exact understanding of learned prediction features is hard, slowing down their clinical application. New methods for interpreting such models are needed to enable clinical translation. Autoencoders are models that allow visualization of learned features, however they can lack detail in their visualizations and thus, cannot provide guidance on features that hinders their use. We propose a method for understanding relevant learned features by visualizing them in detailed images. We show that a model trained to predict age based on brain MR data learns known features of the aging brain.

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