We present the findings from 1190 presumed healthy patients evaluated at a precision medicine clinic. We performed deep quantitative multimodal phenotyping and genotyping comprising quantitative whole-body imaging, whole genome sequencing, and advanced blood-based biomarkers. Within this cohort, medically significant findings included aneurysms, newly identified tumors, coronary artery disease, metabolic disease, cardiac arrhythmia, myocardial disease, and neurodegenerative risk. Forty percent of “healthy” patients had a new clinically significant finding that was not previously known. For this 40%, we are able to provide quantitative continuous metrics that enable individuals to make informed decisions to mitigate their health risks.