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Abstract #0707

Imaging wound-healing related fibrosis using short inversion time ultra-short TE (STIR-UTE)

Ehud J Schmidt1, Iga Muradyan2, Thomas Benkert3, Himanshu Bhat4, Aravindan Kolandaivelu5, Henry R Halperin5, and Akila N Vaswanathan6

1Medicine (Cardiology), The Johns Hopkins University, Baltimore, MD, United States, 2Radiology, Brigham and Womens Hospital, Boston, MA, United States, 3Application Development, Siemens Healthcare GmbH, Erlangen, Germany, 4MRI, Siemens Healthineers, Boston, MA, United States, 5Medicine (Cardiology), Johns Hopkins University, Baltimore, MD, United States, 6Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States

Collagen deposition occurs during wound-healing processes in several diseases, and following therapy (acute myocardium infarction, radiation induced fibrosis). There is interest in intervening during wound-healing, since chronic scar leads to complications (ventricular tachycardia, gastrointestinal bleeding), with novel medications possibly reducing fibrosis. Intervention requires early detection of diffuse fibrosis (<50% content/voxel) during acute wound-healing. Fibrosis detection with gadolinium-perfusion (LGE, T1 mapping) is problematic during acute disease, due to irregular vascularity. Ultrashort-Time-to-Echo’s (UTE’s) collagen-sensitivity is reduced by fat’s masking signal. With STIR-UTE, we utilize collagen’s short TE and short T1 to suppress fat and map fibrosis in the pelvis, in normal and in post-infarction hearts.

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