Abstract #0733

Gadolinium retention in tissues: yttrium as a gadolinium surrogate to investigate the in vivo biodistribution of the retained gadolinium

Mariane LE FUR¹, Alana Ross¹, and Peter Caravan¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Gadolinium has been found in the brain, skin and bone of patients with normal renal function months to years after the last administration of a gadolinium-based contrast agent (GBCA). Yttrium (Y³⁺) has similar size and chemical properties to Gd³⁺. We investigated whether yttrium can be used as a gadolinium surrogate by measuring the biodistribution of Gd-DTPA/Y-DTPA and Gd-DOTA/Y-DOTA (0.6 mmol/kg) in mice. Residual Gd and Y levels 7 days after injection showed a Y:Gd ratio close to 1 in all organs demonstrating that Y can act as a surrogate for Gd.

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