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Abstract #0737

T2 relaxation times identify acute ischaemic stroke patients within the thrombolysis treatment window with higher accuracy than T2-weighted signal intensities

Bryony McGarry1, Isabel Chew1, Robin Damion1, Michael Knight1, Rose Bosnell2, Peter Jezzard3, George Harston 3, Davide Carone 3, James Kennedy 3, Salwa El-Tawil 4, Jennifer Elliot4, Keith Muir4, Philip Clatworthy2, and Risto Kauppinen1

1School of Psychological Science, University of Bristol, Bristol, United Kingdom, 2North Bristol NHS Trust, Bristol, United Kingdom, 3University of Oxford, Oxford, United Kingdom, 4University of Glasgow, Glasgow, United Kingdom

Unknown symptom onset time is a common contraindication for thrombolysis of hyperacute ischaemic stroke. MRI may identify patients within the 4.5-hour thrombolysis treatment window, but it is unclear which parameter is most accurate. We compared the ability of hemispheric differences in quantitative T2 (qT2), ADC, and signal intensities of DWI, T2-weighted and T2-weighted FLAIR images at distinguishing between patients scanned within and beyond 4.5-hours. qT2 correlated significantly with time from onset (r = .491, p =.003) and had the highest and only significant AUC (0.77, p = .007). These data point to qT2 as a stroke timer.

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