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Abstract #0749

Brain state and CSF production define glymphatic washout in the rat brain

Martin Segeroth1, Lydia Wachsmuth1, Franziska Albers1, and Cornelius Faber1

1Translational Research Imaging Center (TRIC), University Hospital Muenster, Muenster, Germany

The Glymphatic System, which is essential for brain-wide waste clearance, is enhanced during sleep. Here, we investigate the effect of brain state and CSF formation using constrast enhanced MRI in a rat model. Our data support the hypothesis that sleep enhances glymphatic clearance due to better CSF intrusion into the brain parenchyma caused by higher CSF formation and smaller arteries. Higher diffusion in cortex associated with altered brain state during sleep influence CSF distribution within parenchyma.

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