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Abstract #0751

Elucidating brain water management in hypertension: a preclinical MRI study

Daphne MP Naessens1, Bram F Coolen1, Judith de Vos1, Ed T van Bavel1, Gustav J Strijkers1, and Erik NTP Bakker1

1Department of Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam, Netherlands

Hypertension has been associated with alterations in vascular function and an imbalanced water management of brain tissue, yet the underlying mechanisms for these pathologies remain unclear. To further elucidate possible mechanisms of the fluid homeostasis in the brain, we performed non-invasive MR imaging on normotensive and spontaneous hypertensive rats. We assessed total brain and regional brain volumes, as well as diffusional and water exchange properties of the brain tissue.

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