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Abstract #0787

Assessment of postinfarct myocardium metabolic degradation with amide proton transfer magnetic resonance imaging at 3 Tesla

Yin Wu1, Kaiyue Diao2, Jie Liu1, Chunchao Xia2, Min Ma3, Yong He3, Hairong Zheng1, and Yingkun Guo4

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 3Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China, 4Department of Radiology, West China Second Hospital, Sichuan University, Chengdu, China

Myocardium ischemia irritates a series of metabolic degradations, including intracellular acidosis and cell damage. Amide proton transfer (APT) effect is associated with microenvironment acidosis and amide protons inside of cytoplasm. In this study, APT imaging was performed on MI patients at 3 Tesla. Results show significant APT effect reduction from the remote (4.29±2.00%), adjacent (2.74±1.18%) to the infarct (1.43±0.80%) regions (P<0.05), implying progressively metabolic alterations from surrounding tissue to the infarct core. The method provides a novel way for noninvasive assessment of myocardium metabolic degradation postinfarction, promising to facilitate therapeutic decision and treatment evaluation.

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