We performed a longitudinal large animal pre-clinical study to assess post-MI temporal alterations of myocardial microstructure, using Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR). In vivo CMR was performed before, at 3 days, and 4 months after the reperfused MI procedure. Remodeled hearts demonstrated reduced right-handed helix angles in the endocardium of the infarct region, as well as a decreased gradient in the healix angle line profiles with associated thinning of the myocardium. Reduced sheetlet angle (E2A) mobility in the acute stage was associated with the development of adverse LV remodeling.
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