Meeting Banner
Abstract #0790

Diffusion Tensor CMR a potential early marker of remodelling after myocardial infarction

Sonia Nielles-Vallespin1,2, Pedro F Ferreira1,2, Andrew D Scott1,2, Dudley J Pennell1,2, David N Firmin1,2, Andrew E Arai3, and Ranil de Silva1,2

1Royal Brompton Hospital, London, United Kingdom, 2Imperial College London, London, United Kingdom, 3National Institutes of Health, Bethesda, MD, United States

We performed a longitudinal large animal pre-clinical study to assess post-MI temporal alterations of myocardial microstructure, using Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR). In vivo CMR was performed before, at 3 days, and 4 months after the reperfused MI procedure. Remodeled hearts demonstrated reduced right-handed helix angles in the endocardium of the infarct region, as well as a decreased gradient in the healix angle line profiles with associated thinning of the myocardium. Reduced sheetlet angle (E2A) mobility in the acute stage was associated with the development of adverse LV remodeling.

This abstract and the presentation materials are available to members only; a login is required.

Join Here