Magnetic Resonance Fingerprinting with quadratic RF phase (qRF-MRF) has previously been reported for simultaneous quantitative mapping of T1, T2 and T2* relaxation times and off resonance for 2D acquisitions. Translation of qRF-MRF to 3D bears practical limitations for reconstruction and dictionary matching due to increase in data and dictionary sizes. Here, randomized SVD based time compression and reduction in dictionary size with quadratic fit are combined to overcome prohibitively large datasets and long reconstruction times of 3D qRF-MRF. Whole brain 3D qRF-MRF can be acquired in 5 minutes and is compared to 2D qRF-MRF and 3D FISP.
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