Abstract #0828

Reperfusion into Severely Damaged Brain Tissue is Associated with Impending Parenchymal Hemorrhage in Recanalized Acute Ischemic Stroke Patients

Samantha Jenny Ma¹, Songlin Yu^2,3, David S. Liebeskind², Xin J. Qiao⁴, Lirong Yan¹, Xin Lou⁵, Jeffrey Saver², Noriko Salamon⁴, and Danny JJ Wang^1,2

¹Stevens Institute of Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States, ²Neurology, UCLA, Los Angeles, CA, United States, ³Neurosurgery, Beijing Tiantan Hospital, Beijing, China, ⁴Radiology, UCLA, Los Angeles, CA, United States, ⁵Radiology, Chinese PLA General Hospital, Beijing, China

While timely reperfusion can reduce more extensive brain tissue injury by salvaging reversibly damaged penumbra, late recanalization also carries the risk of causing additional and substantial brain damage, such as ischemia-reperfusion injury, compared with no revascularization. The reperfusion status after thrombolysis within the DWI lesion territory and its relationship with HT is unclear, leaving the details regarding post-treatment care unspecified. In this study, we aim to quantify the volume of reperfusion into severely damaged brain tissue and investigate its predictive value for impending parenchymal hematoma following recanalization.

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