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Abstract #0830

Dual Contrast MRI for Visualization of Whole Brain Macro and Microvascular Remodeling in Rat Ischemic Stroke Model

MungSoo Kang1, DongKyu Lee1, SeokHa Jin1, and HyungJoon Cho1

1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea, Republic of

Because of therapeutic and prognostic significance, the visualizations and quantifications of vascular remodelings are crucial for ischemic stroke brains. In this work, dual contrast MRI was implemented on tMCAO rats as an ischemic stroke model to visualize whole-brain macro- and micro-vascular remodeling. In additional to R1 based UTE-MRA, which showed macrovascular remodeling, simultaneously acquired VSI, Q and MVD metrics from ΔR2-ΔR2*-MRI showed microvascular remodeling in ischemic reperfused rat brains.

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