Abstract #0838

Evaluating multi-site rCBV consistency from DSC-MRI imaging protocols and post-processing software across the NCI Quantitative Imaging Network sites using a Digital Reference Object

Laura C. Bell¹, Natenael Semmineh¹, Hongyu An², Cihat Eldeniz², Richard Wahl², Kathleen Schmainda³, Melissa Prah³, Bradley Erickson⁴, Panagiotis Korfiatis⁴, Chengyue Wu⁵, Anna Sorace⁵, Neal Rutledge⁵, Thomas Yankeelov⁵, Thomas Chenevert⁶, Dariya Malyarenko⁶, Yichu Liu⁷, Andrew Brenner⁷, Leland Hu⁸, Yuxiang Zhou⁸, Jerrold Boxerman⁹, Yi-Fen Yen¹⁰, Jayashree Kalpathy-Cramer¹⁰, Andrew Beers¹⁰, Mark Muzi¹¹, Ananth Madhuranthakam¹², Marco Pinho¹², Brian Johnson^12,13, and C. Chad Quarles¹

¹Barrow Neurological Institute, Phoenix, AZ, United States, ²Washington University in St. Louis, St. Louis, MO, United States, ³Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Mayo Clinic, Rochester, MN, United States, ⁵The University of Texas at Austin, Austin, TX, United States, ⁶University of Michigan, Ann Arbor, MI, United States, ⁷University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, ⁸Mayo Clinic, Scottsdale, AZ, United States, ⁹Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States, ¹⁰Massachusetts General Hospital, Boston, MA, United States, ¹¹University of Washington, Seattle, WA, United States, ¹²The University of Texas Southwestern, Dallas, TX, United States, ¹³Philips, Gainesville, FL, United States

Differences in imaging protocols (IP) and post-processing methods (PM) may influence relative cerebral blood volume (rCBV). Our goal was to leverage a dynamic susceptibility contrast (DSC) DRO to characterize rCBV consistency across 12 sites, focusing on differences due to site-specific IPs and/or PMs. Our results indicate high agreement when one center processes rCBV despite slight variations in the IP. However, substantial disagreement was observed when site-specific software was applied for rCBV measurements. These results have important implications for comparing DSC-MRI data across sites/trials, where PM variability could confound the use of rCBV as a biomarker of therapy response.

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