Abstract #0846

Glomerular filtration rate estimation by motion-robust high spatiotemporal resolution DCE-MRI with radial VIBE and comparison with plasma clearance of 99mTc-DTPA

Sila Kurugol¹, Onur Afacan¹, Alto Stemmer², Richard S. Lee³, Jeanne S. Chow¹, and Simon K. Warfield¹

¹Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States, ²Siemens Healthcare, Erlangen, Germany, ³Urology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States

The accuracy of MRI based glomerular filtration rate (GFR) measurements using the standard Cartesian VIBE DCE-MRI is limited by motion and temporal resolution. Instead, we use motion-robust high temporal resolution radial VIBE for DCE-MRI for accurate estimation of GFR. We optimize its temporal resolution and compressed sensing reconstruction temporal regularization parameters to obtain an accurate arterial input function peak while reconstructing good quality images. We also developed a fully automated segmentation and tracer kinetic model-fitting pipeline to compute MRI-GFR. We assessed the accuracy of proposed technique to measure GFR by comparing MRI-GFR to GFR from 99mTcDTPA nuclear medicine study (NMGFR).

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