This study tests the hypothesis that quantitative T2* and UTE-T2* are sensitive to ACL graft changes reflective of histological stages of human ACL graft incorporation following ACL reconstruction. T2* variability at 6 months suggests transition from early stage incorporation to remodeling, while stable values from 6 months to 1 year are consistent with remodeling. ACL graft T2* and UTE-T2*, respectively, from two different cohorts decreased between 1 and 2 years suggesting continued graft maturation during the second year. T2* and UTE-T2* of ACL graft incorporation may help to inform decisions concerning return to sports and work activities following ACL reconstruction.
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