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Abstract #0865

Assessment of an In Vitro Model of Rotator Cuff Tendinopathy Using 3D-UTE MRI Biomarkers with Biochemical and Histological Correlation

Tan Guo1,2, Rachel High1, Qingbo Tang3, Jonathan Wong1,3, Yajun Ma1, Adam Searleman1, Sarah To3, Lidi Wan1, Saeed Jerban1, Jiang Du1, and Eric Y Chang1,3

1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, Beijing Hospital, Beijing, China, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Changes in extracellular matrix are seen in cuff tendinopathy, and in particular, alterations in collagen proportion and property are characteristic. Tendon contains an abundance of short T2 components that rapidly decay to background levels. Thus, UTE sequences are better suited for quantitative evaluation of tendon compared with standard clinical MR sequences. In this study, we assess the sensitivity of multiple UTE biomarkers for the evaluation of rotator cuff degeneration in a controlled laboratory experiment.

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