Abstract #0865

Assessment of an In Vitro Model of Rotator Cuff Tendinopathy Using 3D-UTE MRI Biomarkers with Biochemical and Histological Correlation

Tan Guo^1,2, Rachel High¹, Qingbo Tang³, Jonathan Wong^1,3, Yajun Ma¹, Adam Searleman¹, Sarah To³, Lidi Wan¹, Saeed Jerban¹, Jiang Du¹, and Eric Y Chang^1,3

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Radiology, Beijing Hospital, Beijing, China, ³Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Changes in extracellular matrix are seen in cuff tendinopathy, and in particular, alterations in collagen proportion and property are characteristic. Tendon contains an abundance of short T2 components that rapidly decay to background levels. Thus, UTE sequences are better suited for quantitative evaluation of tendon compared with standard clinical MR sequences. In this study, we assess the sensitivity of multiple UTE biomarkers for the evaluation of rotator cuff degeneration in a controlled laboratory experiment.

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