Abstract #0868

[18F]-NaF PET-MR Imaging Reveals Bone-Cartilage Interactions in Hip Osteoarthritis

Radhika Tibrewala¹, Emma Bahroos¹, Hatef Mehrebian¹, Sarah C Foreman¹, Thomas M Link¹, Valentina Pedoia¹, and Sharmila Majumdar¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

In Osteoarthritis (OA), degeneration of articular cartilage can be accompanied by changes in bone structure. In this study, we analyzed the distribution of [¹⁸F]-NaF uptake and blood flow in the femur and acetabulum in 10 hip OA patients and studied associations between bone remodeling and cartilage composition in the presence of morphological abnormalities using PET-MR, quantitative MR and femur shape modeling. Our results showed associations of Standardized Uptake Values (SUV), blood flow to bone (K_pat) with patient reported pain, when different bone shapes like shaft thickness and coxa valga were taken into account.

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