Abstract #0870

IVIM Analysis in Response Evaluation of Osteosarcoma Treated with Neoadjuvant Chemotherapy: Correlation with Histopathological Necrosis

Esha Baidya Kayal¹, Devasenathipathy Kandasamy², Kedar Khare³, Raju Sharma², Sameer Bakhshi⁴, and Amit Mehndiratta^1,2

¹Center for Biomedical Engineering, Indian Institute of Technology, Delhi, India, New Delhi, India, ²Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ³Department of Physics, Indian Institute of Technology, Delhi, India, New Delhi, India, ⁴Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India

Histological necrosis is the current gold standard for response evaluation in osteosarcoma treated with neoadjuvant chemotherapy (NACT). However it is applicable only after tumor resection on completion of NACT. Thus, a non-invasive early marker of NACT response is desirable. We performed NACT response prediction and evaluation using Intra-voxel Incoherent Motion (IVIM) Diffusion weighted MRI and histogram analysis. IVIM parameters and its histogram analysis revealed clinically useful information in characterizing and predicting chemotherapy response to Osteosarcoma.

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