Abstract #0885

Functional Connectivity Mediates the Relationship between Regional Excitation-Inhibition Balance and Default-Mode Network Deactivation

Hong Gu¹, Yuzheng Hu^1,2, Xi Chen^1,3, Yong He⁴, and Yihong Yang¹

¹Neuroimaging Research Branch, National Institue on Drug Abuse, Baltimore, MD, United States, ²Department of Psychology, Zhejiang University, Hangzhou, China, ³Harvard Medical School, Boston, MA, United States, ⁴Beijing Normal University, Beijing, China

Aberrant default mode network (DMN) activity has been related to aging and various neuropsychiatric illnesses. To better understand the neural mechanisms underlying the DMN deactivation, we investigated the triple-relationship among the task-induced deactivation, regional excitation-inhibition balance, and the interregional functional connectivity strength associated with the DMN. Using mediation analysis, we found that the network interaction between DMN and the salience network partially mediated the association between the regional excitation-inhibition balance and the DMN deactivation. This finding bridges DMN-deactivation related findings from various neuroimaging modalities and may provide new insights into the neural mechanisms of the DMN deactivation.

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