Abstract #0913

Dynamic functional connectivity and its relation to structural rich-club organisation

Marion Sourty¹, Andrew Zalesky^2,3, and Fernando Calamante^1,4,5

¹School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, Australia, ²Melbourne School of Engineering, The University of Melbourne, Melbourne, Australia, ³Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia, ⁴Sydney Imaging, The University of Sydney, Sydney, Australia, ⁵Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia

The relationship between static functional connectivity (FC) and structural connectivity (SC) has been long-recognised. More recently, functional connectivity has increasingly focused on the investigation of temporal variations of the BOLD fMRI signal; however, the role of SC on the observed FC fluctuations is not trivial or well understood. We show here that the structural rich-club organisation of the brain better describes the FC fluctuations than simply considering SC strength.

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