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Abstract #0913

Dynamic functional connectivity and its relation to structural rich-club organisation

Marion Sourty1, Andrew Zalesky2,3, and Fernando Calamante1,4,5

1School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, Australia, 2Melbourne School of Engineering, The University of Melbourne, Melbourne, Australia, 3Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia, 4Sydney Imaging, The University of Sydney, Sydney, Australia, 5Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia

The relationship between static functional connectivity (FC) and structural connectivity (SC) has been long-recognised. More recently, functional connectivity has increasingly focused on the investigation of temporal variations of the BOLD fMRI signal; however, the role of SC on the observed FC fluctuations is not trivial or well understood. We show here that the structural rich-club organisation of the brain better describes the FC fluctuations than simply considering SC strength.

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