Multiple sclerosis (MS) is the most common immune-mediated demyelinating inflammatory disease, afflicting over 2.3 million people globally. Magnetic resonance imaging (MRI) is the gold standard non-invasive imaging modality to identify MS lesions. Clinically, both CSF-suppressed T2-weighted and T1-weighted images are used for the characterization of MS lesions (FLAIR and MP-RAGE sequences). However, these sequences are not specific for demyelinating lesions and can be challenging to interpret. In this study, we propose a direct myelin imaging technique utilizing IR-prepared hybrid encoded UTE imaging, which provides highly specific volumetric myelin images with scan time less than 7min.
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