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Abstract #0939

Direct Myelin Imaging In Human Brain Using Inversion Recovery Hybrid Encoded Ultrashort Echo Time (IR-HE-UTE) Magnetic Resonance Imaging

Hyungseok Jang1, Yajun Ma1, Adam C Searleman1, Michael Carl2, Jody Corey-Bloom3, Eric Y Chang1,4, and Jiang Du1

1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Department of Neurosciences, University of California San Diego, San Diego, CA, United States, 4Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Multiple sclerosis (MS) is the most common immune-mediated demyelinating inflammatory disease, afflicting over 2.3 million people globally. Magnetic resonance imaging (MRI) is the gold standard non-invasive imaging modality to identify MS lesions. Clinically, both CSF-suppressed T2-weighted and T1-weighted images are used for the characterization of MS lesions (FLAIR and MP-RAGE sequences). However, these sequences are not specific for demyelinating lesions and can be challenging to interpret. In this study, we propose a direct myelin imaging technique utilizing IR-prepared hybrid encoded UTE imaging, which provides highly specific volumetric myelin images with scan time less than 7min.

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