Meeting Banner
Abstract #0941

Efficient whole-brain tract-specific T1 mapping with slice-shuffled inversion-recovery diffusion-weighted imaging at 3T

Daniel A. Andrews1,2, Jennifer S. W. Campbell1, Ilana R. Leppert1, Daniel J. Park3, G. Bruce Pike1,2,4,5, Jonathan R. Polimeni3,6,7, and Christine L. Tardif1,2,8

1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, 2Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 5Department of Radiology and Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, 6Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 7Department of Radiology, Harvard Medical School, Harvard University, Boston, MA, United States, 8Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

The majority of voxels in magnetic resonance images of human white matter contain crossing tracts. Conventional T1 mapping techniques are sensitive to the myelin content of the entire voxel and are thus non-specific to individual tract myelination. We recently proposed an efficient slice-shuffled, multiband accelerated inversion-recovery diffusion-weighted MRI (IR-DWI) sequence at 3 Tesla. Here we demonstrate that IR-DWI can be used to estimate tract-specific T1 in voxels with crossing fibres in a phantom and in a healthy subject in a reasonable scan time.

This abstract and the presentation materials are available to members only; a login is required.

Join Here