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Abstract #0951

Preliminary detailed in-vivo brain atlas of metabolic and macromolecular distributions in humans using 7T 1H Magnetic Resonance Spectroscopic Imaging

Alex A Bhogal1, Tommy AA Broeders1, Mirte EJ Edens1, Sahar Nassirpour2,3, Paul Chang2,3, Peter R Luijten1, Dennis WJ Klomp1, Christiaan H Vinkers1,4, and Jannie P Wijnen1

1University Medical Center Utrecht, Utrecht, Netherlands, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3IMPRS for Cognitive and Systems Neuroscience, Eberhard Karls University of Tübingen, Tübingen, Germany, 4Amsterdam University Medical Center, Amsterdam, Netherlands

This study amalgamated current state-of-the-art MRSI developments to create a detailed and reliable in vivo metabolic atlas of the healthy human brain. We used an ultra-high field 7T MR scanner to acquire high resolution, short echo-time (TE) MRSI data along with an external crusher coil for hardware based extra-cranial lipid signal suppression. Advanced post-processing and data reconstruction techniques were used in conjunction with stringent data filtering based on several quality assurance metrics, while registration to the MNI152 standard atlas allowed us to generate high-resolution metabolite/macromolecule ratio maps.

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