Abstract #0953

Whole-slice mapping of GABA and GABA+ at 7T via adiabatic MEGA-editing, real-time instability correction, and concentric circle readout

Philipp Moser¹, Lukas Hingerl¹, Bernhard Strasser², Michal Považan³, Gilbert Hangel¹, Ovidiu C. Andronesi², Andre van der Kouwe², Stephan Gruber¹, Siegfried Trattnig^1,4, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Christian Doppler Laboratory for Clinical Molecular MRI, Vienna, Austria

In vivo detection of γ-aminobutyric acid (GABA) and glutamate (Glu), both major neurotransmitters in the human brain, benefits from the higher sensitivity at ultra-high field (7T) compared to lower field strengths. However, strong B₀/B₁⁺ inhomogeneities and chemical shift displacement errors as well as subject motion and frequency drifts can significantly impair the experiment. An adiabatic MEGA-editing scheme was developed and incorporated into a real-time corrected B₁⁺-insensitive MRSI sequence, which enabled whole-slice metabolic imaging of neurotransmitters in the human brain with unprecedented high-resolution at 7T and allowed a comprehensive assessment of regional GABA levels without co-edited macromolecule contamination.

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