Meeting Banner
Abstract #0953

Whole-slice mapping of GABA and GABA+ at 7T via adiabatic MEGA-editing, real-time instability correction, and concentric circle readout

Philipp Moser1, Lukas Hingerl1, Bernhard Strasser2, Michal Považan3, Gilbert Hangel1, Ovidiu C. Andronesi2, Andre van der Kouwe2, Stephan Gruber1, Siegfried Trattnig1,4, and Wolfgang Bogner1

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Christian Doppler Laboratory for Clinical Molecular MRI, Vienna, Austria

In vivo detection of γ-aminobutyric acid (GABA) and glutamate (Glu), both major neurotransmitters in the human brain, benefits from the higher sensitivity at ultra-high field (7T) compared to lower field strengths. However, strong B0/B1+ inhomogeneities and chemical shift displacement errors as well as subject motion and frequency drifts can significantly impair the experiment. An adiabatic MEGA-editing scheme was developed and incorporated into a real-time corrected B1+-insensitive MRSI sequence, which enabled whole-slice metabolic imaging of neurotransmitters in the human brain with unprecedented high-resolution at 7T and allowed a comprehensive assessment of regional GABA levels without co-edited macromolecule contamination.

This abstract and the presentation materials are available to members only; a login is required.

Join Here