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Abstract #0961

Microstructural Changes of Normal-Appearing White Matter in Vascular Parkinsonism

Maria Eugenia Caligiuri1,2, Maria Salsone2, Andrea Quattrone3, Michaela Montilla4, Ivan Rektor4, and Aldo Quattrone1,2

1Neuroscience Research Center, University Magna Graecia of Catanzaro, Catanzaro, Italy, 2Neuroimaging Unit, Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Catanzaro, Italy, 3Institute of Neurology, University Magna Graecia of Catanzaro, Catanzaro, Italy, 4Masaryk University, Central European Institute of Technology (CEITEC), Brno, Czech Republic

White matter hyperintensities (WMH) play a crucial role in the pathogenesis of Vascular Parkinsonism (VP), a clinical entity characterized by parkinsonism, postural instability, marked gait difficulty and poor levodopa response. However, involvement of normal-appearing white matter (NAWM) in VP still remains unknown. Here we analyzed NAWM microstructure in VP compared to Parkinson’s disease (PD) and controls using MRI and DTI. We found extensive DTI alterations in VP, but not in PD nor in controls. NAWM damage in the genu of corpus callosum correlated with clinical core features such as postural instability, freezing-of-gait and symmetry of parkinsonism.

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