Abstract #0964

Structural and functional organization of the brain connectome in patients with different motor neuron diseases: a multicenter study

Camilla Cividini¹, Federica Agosta¹, Silvia Basaia¹, Francesca Trojsi², Nilo Riva³, Cinzia Femiano², Cristina Moglia⁴, Edoardo G. Spinelli¹, Maria Rosaria Monsurrò², Yuri Falzone³, Andrea Falini⁵, Giancarlo Comi³, Adriano Chiò⁴, Gioacchino Tedeschi², and Massimo Filippi^1,3

¹Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy, ³Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ⁴ALS Center, ‘Rita Levi Montalcini’ Department of Neuroscience, University of Torino, Torino, Italy, ⁵Department of Neuroradiology and CERMAC, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

We investigated structural and functional brain network topology in amyotrophic (ALS), primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) patients and in healthy controls (HC), using graph analysis and connectomics. ALS and PLS patients showed widespread microstructural alterations in sensorimotor network, basal ganglia area and prefrontal cortex and posterior brain regions compared to HC, while PMA subjects did not show significant brain damages. All groups had a relatively preserved global and local functional connectome properties compared to each other. Graph analysis and connectomics might represent a powerful approach to understand the pathophysiological process associated with motor neuron diseases.

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