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Abstract #0969

A Variable Flip Angle Golden-Angle-Ordered 3D Stack-of-Radial Sequence for Combined PRF/T1 Monitoring of MR-Guided HIFU Ablation

Le Zhang1, Tess Armstrong1,2, Xinzhou Li1,3, and Holden H. Wu1,2,3

1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Proton resonance frequency (PRF) shift is widely used for MR temperature mapping, but fails in adipose tissues. T1 measurement offers an alternative temperature mapping method in adipose tissues. Combined PRF-T1 temperature mapping has been evaluated for Cartesian MRI, but there is a lack of research for non-Cartesian techniques. In this work, we propose a new 3D stack-of-radial technique for combined PRF-T1 MR temperature mapping. Results from non-heating in vivo scans demonstrate good stability of T1 and PRF measurements. Data from ex vivo high-intensity focused ultrasound (HIFU) ablations demonstrate good agreement between both PRF and T1 mapping compared to temperature probes.

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