This study validates prostate tissue composition measured non-invasively using Hybrid Multidimensional MRI (HM-MRI) with ground truth reference standard quantitative histology results from whole mount prostatectomy. There was no significant difference in prostate tissue composition measured using HM-MRI and quantitative histology with excellent correlation (0.89) and agreement on Bland-Altman analysis (bias <5%). There is significant difference in epithelium and lumen volume between cancer and normal tissue with high area under the ROC curve (0.87-0.95). This study demonstrates that the tissue composition measured using HM-MRI matches very closely with ground truth quantitative histology measures and can be used for non-invasive prostate cancer diagnosis.
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