In vivo measurement of cellular-interstitial water exchange rate remains non-trivial. Its development is also hampered by the lack of a gold standard method for validation. In this study, we have used two complementary diffusion MRI methods to measure the water exchange rates. Time-dependent diffusional kurtosis imaging was used to measure the water exchange rate ($$$\tau_{ex}$$$) between the intra- and extra-cellular spaces, while a constant gradient diffusion MRI experiment was used to measure the intracellular water lifetime ($$$\tau_i$$$). These two measurements were conducted using GL261, a mouse glioma tumor model.
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