Abstract #1022

Direct Radiologic-Pathologic Correlation of Liver Lesions with an MR-Compatible Sectioning and Localization Device

Victoria R. Rendell¹, Timothy J. Colgan², Gesine Knobloch², Matthias R. Muhler², Agnes G. Loeffler³, Rashmi M. Agni³, Krisztian Kovacs³, Emily R. Winslow¹, and Scott B. Reeder⁴

¹Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ²Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ³Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁴Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine., University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

The purpose of this study was to demonstrate the feasibility of a novel method for precise radiologic-pathologic correlation of liver metastases, in patients undergoing curative resection. Intraoperative gadoxetic acid was administered to patients at the time of partial hepatectomy prior to vascular inflow ligation. Ex vivo MRI was then performed using an MR-compatible sectioning device to identify lesion coordinates to inform pathologic processing. Results from resection specimens in 6 patients with a total of 25 liver lesions are presented. The study’s novel radiologic-pathologic correlation method combines intraoperative gadoxetic acid administration and ex vivo MR imaging to perform accurate lesion localization.

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