Abstract #1026

Liver glycogen concentration and body hydration status are predictors of liver shMOLLI T1 measurements

Ferenc E Mozes¹, Ladislav Valkovic^1,2, Michael Pavlides¹, Matthew D Robson^1,3, and Elizabeth M Tunnicliffe¹

¹Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ³Perspectum Diagnostics, Oxford, United Kingdom

Liver T₁ measurements can be used to characterise liver disease but are also sensitive to physiologically normal liver changes. In this work, a set of metabolic interventions were performed to assess the effect of liver glycogen concentration and body hydration status on liver shMOLLI T₁ measurements in healthy volunteers. Glycogen showed an in vivo relaxivity in keeping with literature phantom data and hydration status showed a smaller effect. Our results will impact the way T₁ measurements of participants with impaired glycogen storage are interpreted, as well as instructions given to participants before their scans.

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