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Abstract #1026

Liver glycogen concentration and body hydration status are predictors of liver shMOLLI T1 measurements

Ferenc E Mozes1, Ladislav Valkovic1,2, Michael Pavlides1, Matthew D Robson1,3, and Elizabeth M Tunnicliffe1

1Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 3Perspectum Diagnostics, Oxford, United Kingdom

Liver T1 measurements can be used to characterise liver disease but are also sensitive to physiologically normal liver changes. In this work, a set of metabolic interventions were performed to assess the effect of liver glycogen concentration and body hydration status on liver shMOLLI T1 measurements in healthy volunteers. Glycogen showed an in vivo relaxivity in keeping with literature phantom data and hydration status showed a smaller effect. Our results will impact the way T1 measurements of participants with impaired glycogen storage are interpreted, as well as instructions given to participants before their scans.

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