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Abstract #1033

Comparison of FerriScan- versus R2*-Derived Liver Iron Concentration (LIC) for Clinical Decision Making in Patients with Liver Iron Overload Disease

Marshall Stephen Sussman1, Kevin Kuo2, Richard Ward2, George Tomlinson3, and Kartik Jhaveri1

1Medical Imaging, University Health Network, Toronto, ON, Canada, 2Division of Medical Oncology & Hematology, University Health Network, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada

This study compared clinical decision making between FerriScan and an R2*-based method in patients with iron overload disease. FerriScan is the current gold standard. However, it is expensive, and data must be transferred offsite. FerriScan and R2* techniques were both used to manage (simulated) patient chelator dosing. The agreement between different reviewers assessing the same FerriScan data was the same as the agreement when the same reviewer used R2*- compared to FerriScan-derived LIC values. Thus, switching to R2*-based decision making from FerriScan is no more likely to cause a difference in patient management than switching from one hematologist to another.

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