Abstract #1065

Cardiac creatine quantified by cycled water-suppressed 1H-MRS at 3T

Belinda Ding^1,2, Mark A Peterzan², Ferenc E Mózes², Hannah A Lake³, Craig A Lygate³, Rana A Sayeed⁴, Mario Petrou⁴, George Krasopoulos⁴, Oliver J Rider², Ladislav Valkovič^2,5, and Christopher T Rodgers^1,2

¹University of Cambridge, Cambridge, United Kingdom, ²Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ³Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom, ⁵Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Science, Bratislava, Slovakia

This work aimed to use cardiac 3T ¹H-MRS to quantify creatine concentration (“[Cr]”) in the human heart, because creatine plays a key role in cardiac energy metabolism. We implemented a cycled water-suppression scheme (WC) into the PRESS and STEAM pulse sequences on a Siemens 3T Prisma MRI scanner. Compared to the vendor’s product PRESS sequence, we found that PRESS-WC was able to measure [Cr] more than 2 times more reproducibly and in a shorter scan. Using PRESS WC in a 10-breathhold protocol, we were able to detect a decrease in creatine concentration in 5 patients suffering from aortic stenosis.

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