Meeting Banner
Abstract #1065

Cardiac creatine quantified by cycled water-suppressed 1H-MRS at 3T

Belinda Ding1,2, Mark A Peterzan2, Ferenc E Mózes2, Hannah A Lake3, Craig A Lygate3, Rana A Sayeed4, Mario Petrou4, George Krasopoulos4, Oliver J Rider2, Ladislav Valkovič2,5, and Christopher T Rodgers1,2

1University of Cambridge, Cambridge, United Kingdom, 2Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 3Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom, 5Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Science, Bratislava, Slovakia

This work aimed to use cardiac 3T 1H-MRS to quantify creatine concentration (“[Cr]”) in the human heart, because creatine plays a key role in cardiac energy metabolism. We implemented a cycled water-suppression scheme (WC) into the PRESS and STEAM pulse sequences on a Siemens 3T Prisma MRI scanner. Compared to the vendor’s product PRESS sequence, we found that PRESS-WC was able to measure [Cr] more than 2 times more reproducibly and in a shorter scan. Using PRESS WC in a 10-breathhold protocol, we were able to detect a decrease in creatine concentration in 5 patients suffering from aortic stenosis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here