Abstract #1069

About the need for a comprehensive description of the macromolecular baseline signal for MR fingerprinting and multidimensional fitting of MR spectra

Maike Hoefemann¹, Christine Bolliger¹, Jan Willem van der Veen², and Roland Kreis¹

¹University of Bern, Departments of Radiology and Biomedical Research, Bern, Switzerland, ²NIH, NIMH, Magnetic Resonance Spectroscopy Core, Bethesda, MD, United States

The purpose of this study was to evaluate the need for a comprehensive description of the macromolecular baseline signal (MMBL), e.g. for MR fingerprinting and multidimensional fitting of MR spectra. Inherent J-evolution for certain signals as well as multi-component T₂-decays can cause variance of the signal shape as function of TE that is not described in a mono-exponential decay model. Two methods are described to accommodate this signal behavior when fitting a 2DJ-Inversion-Recovery dataset. In addition, the MMBLs for different TEs, as well as resulting metabolite contents, T₁s and T₂s with the conventional and alternative methods are reported.

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