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Abstract #1083

Shear wave MR elastography using intrinsic cardiac motion for the non-invasive evaluation of myocardial stiffness: initial results in volunteers and HCM patients.

Marian Troelstra1,2, Emma Burnhope1, Jurgen Runge1,2, Alessandro Polcaro1,3, Torben Schneider4, Jordi Martorell3, David Nordsletten1,5, Tevfik Ismail1, and Ralph Sinkus1,6

1Department of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 3Department of Chemical Engineering, IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain, 4Philips Healthcare, Guildford, United Kingdom, 5Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States, 6Laboratory for Vascular Translational Science, INSERM, Paris, France

Imaging myocardial stiffness provides useful clinical information in various cardiac conditions and diseases. We developed an intrinsic shear wave MRE method for determining shear wave speed in the interventricular septum using an adapted motion-sensitised pencil beam respiratory navigator sequence (cRNAV). Time of flight between two imaged locations in the basal and apical septum was used to estimate flexural shear wave velocity. Initial testing provided promising results in healthy volunteers and two patients with hypertrophic cardiomyopathy (HCM).

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