Abstract #1083

Shear wave MR elastography using intrinsic cardiac motion for the non-invasive evaluation of myocardial stiffness: initial results in volunteers and HCM patients.

Marian Troelstra^1,2, Emma Burnhope¹, Jurgen Runge^1,2, Alessandro Polcaro^1,3, Torben Schneider⁴, Jordi Martorell³, David Nordsletten^1,5, Tevfik Ismail¹, and Ralph Sinkus^1,6

¹Department of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ³Department of Chemical Engineering, IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain, ⁴Philips Healthcare, Guildford, United Kingdom, ⁵Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States, ⁶Laboratory for Vascular Translational Science, INSERM, Paris, France

Imaging myocardial stiffness provides useful clinical information in various cardiac conditions and diseases. We developed an intrinsic shear wave MRE method for determining shear wave speed in the interventricular septum using an adapted motion-sensitised pencil beam respiratory navigator sequence (cRNAV). Time of flight between two imaged locations in the basal and apical septum was used to estimate flexural shear wave velocity. Initial testing provided promising results in healthy volunteers and two patients with hypertrophic cardiomyopathy (HCM).

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