Myocardial viscoelasticity plays an important role in cardiac function. The objective of this study is to evaluate if magnetic resonance elastography (MRE) can detect differences in myocardial stiffness (µ) and damping ratio (ζ) in cardiac amyloidosis patients. Twenty-six patients with cardiac amyloidosis and 96 healthy volunteers were enrolled. The mean left ventricular µ was significantly higher (p < 0.01) and ζ was significantly lower (p<0.01) in cardiac amyloidosis patients (median µ: 19.5 kPa, median ζ: 0.15) compared to normal controls (median µ: 15.7 kPa, median ζ: 0.18). These results motivate future investigation of cardiac MRE in different patient cohorts.
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