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Abstract #1085

Changes in myocardial stiffness and damping ratio due to cardiac amyloidosis: Evaluation with magnetic resonance elastography and a novel neural network inversion

Arvin Arani1, Shivaram P. Arunachalam1, Ian C. Chang1, Phillip J. Rossman1, Kevin Glaser1, Joshua D. Trzasko1, Kiaran P. McGee1, Armando Manduca1, Martha Grogan1, Angela Dispenzieri1, Richard L. Ehman1, Philip A. Araoz1, and Matthew C. Murphy1

1Radiology, Mayo Clinic, Rochester, MN, United States

Myocardial viscoelasticity plays an important role in cardiac function. The objective of this study is to evaluate if magnetic resonance elastography (MRE) can detect differences in myocardial stiffness (µ) and damping ratio (ζ) in cardiac amyloidosis patients. Twenty-six patients with cardiac amyloidosis and 96 healthy volunteers were enrolled. The mean left ventricular µ was significantly higher (p < 0.01) and ζ was significantly lower (p<0.01) in cardiac amyloidosis patients (median µ: 19.5 kPa, median ζ: 0.15) compared to normal controls (median µ: 15.7 kPa, median ζ: 0.18). These results motivate future investigation of cardiac MRE in different patient cohorts.

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